Thyroid Hormone Distributor Proteins During Development in Vertebrates

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Developmentally regulated thyroid hormone distributor proteins in marsupials, a reptile, and fish.

Thyroid hormones are essential for vertebrate development. There is a characteristic rise in thyroid hormone levels in blood during critical periods of thyroid hormone-regulated development. Thyroid hormones are lipophilic compounds, which readily partition from an aqueous environment into a lipid environment. Thyroid hormone distributor proteins are required to ensure adequate distribution of ...

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Developmentally Regulated Thyroid Hormone Distributor Proteins in Marsupials, a Reptile and Fishes

Thyroid hormones are essential for vertebrate development. There is a characteristic rise in thyroid hormone levels in blood during critical periods of thyroid hormone-regulated development. Thyroid hormones are lipophilic compounds, which readily partition from an aqueous environment into a lipid environment. Thyroid hormone distributor proteins are required to ensure adequate distribution of ...

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Regulation of thyroid hormone-induced development in vivo by thyroid hormone transporters and cytosolic binding proteins.

Differential tissue sensitivity/responsivity to hormones can explain developmental asynchrony among hormone-dependent events despite equivalent exposure of each tissue to circulating hormone levels. A dramatic vertebrate example is during frog metamorphosis, where transformation of the hind limb, brain, intestine, liver, and tail are completely dependent on thyroid hormone (TH) but occurs async...

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Frogs model man: In vivo thyroid hormone signaling during development.

Thyroid hormone (TH) signaling comprises TH transport across cell membranes, metabolism by deiodinases, and molecular mechanisms of gene regulation. Proper TH signaling is essential for normal perinatal development, most notably for neurogenesis and fetal growth. Knowledge of perinatal TH endocrinology needs improvement to provide better treatments for premature infants and endocrine diseases d...

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ژورنال

عنوان ژورنال: Frontiers in Endocrinology

سال: 2019

ISSN: 1664-2392

DOI: 10.3389/fendo.2019.00506